Ozempic

Weight Loss With Ozempic

Written by: Jill Team
Reviewed by: Registered Pharmacist & Doctor of Pharmacy Sarah Bento-De Sousa

Ozempic can be a highly effective tool for weight management — as long as you’re eligible for treatment and can get a prescription.

In this article we’ll cover:

  • How Ozempic can help with weight management
  • How Ozempic actually works
  • The weight management benefits of the drug
  • Information about the types of Ozempic and dosage guidelines
  • Risks associated with Ozempic you should know
  • How to manage your health when using Ozempic
  • How long it takes to notice changes on Ozempic
  • Frequently asked questions.

Ready to learn all you need to know? Read on!

Use of Ozempic for Weight Loss

Although initially developed by Novo Nordisk as a medication to help adults with type 2 diabetes control their blood sugar, Ozempic is also a highly effective tool for weight management in those with a BMI of 27 or higher. 

Studies have shown that patients taking the drug were able to — on average — lose significantly more body mass than control groups. Not only that, they have also been able to reduce their risk of major cardiovascular events, including stroke, high blood pressure, heart attack, and death.

How Does Ozempic Contribute to Weight Loss?

Ozempic’s main ingredient is semaglutide, which works by mimicking the action of a hormone in your body known as a glucagon-like peptide-1 (GLP-1) receptor agonist. In type-2 diabetics, this hormone helps regulate your blood sugar levels and with the production of insulin. 

However, its positive side effect is that it can also affect the hunger receptors in the brain as well as slow digestion. This reduces hunger, promotes feelings of fullness and satiety, and delays gastric emptying.

By increasing the levels of GLP-1 in the body, Ozempic can help individuals consume fewer calories, leading to better weight management.

Should You Consider Ozempic for Weight Loss?

Whether or not Ozempic is right for you depends on a number of factors, including your weight, other health conditions, and other medications you take. 

While it has shown great promise in helping individuals with a higher body mass index (BMI) with their weight management goals, Health Canada has not approved Ozempic for use in those with a BMI below 27, or children. 

Additionally, there may be other criteria involved, including efficacy of other medications (with a minimum use period of generally around six months), or other weight-related conditions.

You should be aware that you are unlikely to be covered by your insurance policy unless you satisfy this criteria. You’ll need to talk to your insurance provider for full details of your policy, as well as your medical team to find out if Ozempic is the right choice for you.

Understanding the Mechanism of Ozempic

In order to decide whether Ozempic is something you should try, you need to understand how it works. Let’s dive into the science!

How Does Ozempic Work in Your Body?

Ozempic works by mimicking the actions of GLP-1, a hormone that is naturally produced in your body. GLP-1 has a variety of functions, primarily involved in glucose regulation and appetite control.

When you eat, your blood glucose levels rise. GLP-1 responds by stimulating the pancreas to release insulin, which helps your cells absorb glucose and brings down blood sugar levels. GLP-1 also slows the rate of gastric emptying, which makes you feel full for longer after eating. 

When you take Ozempic, it attaches itself to the GLP-1 receptors, which enhances the natural effects of the GLP-1 hormones. This means you have better glucose management and slower digestion, which leads to reduced appetite and improved weight management.

Key Benefits of Taking Ozempic for Weight Loss

Taking Ozempic for weight loss has several beneficial effects. These include:


  • Reduced appetite

Because Ozempic slows digestion, it makes you feel full for longer. This reduces the desire to eat and can help weight management efforts. 


  • Blood sugar control

Ozempic improves your blood sugar and can reduce the risk of insulin resistance, which is associated with body mass gain.


  • Improved metabolic health

Ozempic can improve your cholesterol and triglyceride levels, which are important markers of health.


  • Less risk of cardiovascular disease

Evidence suggests patients taking Ozempic have a reduced risk of cardiovascular events, including high blood pressure, heart attack, stroke, and heart disease.

Ozempic Types and Dosage Guidelines

Your Ozempic dosing schedule will depend on a number of individual factors, including how well you tolerate the medication and your weight management goals. Dosage is important, and individual weight management is optimized when Ozempic is taken as prescribed.

Different Types of Ozempic Available

Ozempic comes in injectable form, with pre-filled, easy-to-use dosing pens, known as an Ozempic Pen. Each pen comes with four doses (enough for a month’s supply).

There are four different strength pens available in 0.25 mg, 0.5 mg, 1 mg, and 2 mg doses. This range in strengths allows doctors to tailor the dosage according to each individual’s unique needs. 

While most patients typically start at the lower end of this scale with a 0.25 mg per week dose, at the 4 week mark, this will likely be increased to a maintenance dose. This will be the dosage you remain on for the duration of your treatment.

If more blood sugar support is required, after this point the dose may be increased to 1 mg or 2 mg (the highest dose available).

Correct Administration of Ozempic for Weight Loss

Ozempic is taken once a week and is injected by the person subcutaneously, ie, beneath the skin and into the fatty layer of the stomach, arm, or thigh. 

It’s important to make sure you don’t miss a dose, and that you rotate the injection site to avoid irritation.

Your medical team, pharmacist, or Nurse Practitioner will be able to demonstrate how to properly administer your Ozempic. However, if you’re still unsure, Novo Nordisk has a helpful video on their website for reference.

Never share your Ozempic Pen with others, even with a fresh needle, as this could spread infection. For the safety of all, immediately after use, be sure to dispose of your used needle in an approved sharps container.

Potential Risks and Interactions of Ozempic

While Ozempic is considered to be a safe drug, there are a few side effects and some contraindications to be aware of when it comes to taking Ozempic. 

Common Side Effects of Ozempic

As with any medication, Ozempic has some potential side effects. The most common side effects are gastrointestinal and are caused by the slowing of digestion. These include:

  • Nausea
  • Constipation
  • Diarrhea
  • Abdominal pain.

In rare cases, patients may experience more serious side effects. These include:

 

  • Pancreatitis (inflammation of the pancreas)
  • Kidney problems
  • Gallbladder issues
  • Severe allergic reactions
  • Changes in vision or issues with your eyes (diabetic retinopathy)
  • Hypoglycemia
  • Thyroid cancer.

If you experience any persistent or worrying side effects while taking Ozempic, or any of the more severe side effects listed above, discontinue your use immediately and contact your medical team for advice, or visit your local ER.

Who Should Refrain from Using Ozempic?

Ozempic is contraindicated for anyone with a history of thyroid cancer or multiple endocrine neoplasia type 2 (MEN 2), as Ozempic can increase the risk of these conditions. 

It is also not recommended for people with a history of pancreatitis, those with type-1 Diabetes, or those who are going through pregnancy, breastfeeding, or intending on conceiving in the next two months.

If any of this applies to you, talk to your medical team for advice, as they may be able to advise you of other more appropriate treatments.

Potential Drug and Supplement Interactions with Ozempic

You should disclose all current prescription medications, supplements, or vitamins you’re taking to your medical team before starting Ozempic. 

The main drug interaction to watch out for when taking Ozempic is other medications that lower your blood sugar. When used with other type-2 diabetes medications, such as metformin, it may reduce your blood sugar levels dramatically, which could lead to hypoglycemia. 

When it comes to supplements, vitamins and minerals, there is no definitive data suggesting any specific supplements are an issue, other than chromium. Taking this simultaneously may lead to low blood sugar levels, so if you are taking chromium, ensure you disclose this to your medical team.

Managing Health While Using Ozempic

If you do choose to take Ozempic, it’s important to remember Ozempic is not a magic bullet. It is a tool to help you with your weight management goals, but is most effective when paired with other lifestyle intervention, such as a healthy diet and regular exercise.

Obesity and weight management is often psychological as well as physical. Consider therapy to help you address any underlying issues with food, as well as improving your relationship with yourself.

It’s important to stay on top of your mental as well as physical health when undergoing treatment, so ensure that you continue to communicate with your medical team throughout.

Monitoring Blood Sugar Levels During Ozempic Use

Your medical team may ask you to monitor your blood sugar levels while using Ozempic. This is particularly likely if you have diabetes, prediabetes, or a history of blood sugar issues. 

This helps to ensure the medication is effectively managing your condition and can guide any necessary adjustments to dosage or lifestyle. Home monitoring systems can be a practical tool to track blood sugar levels daily. 

Diet and Exercise Recommendations for Optimal Results with Ozempic

Although Ozempic can help control your appetite, it works best when combined with a healthy, balanced diet, and regular exercise. Even if you’re taking Ozempic, you won’t be able to effectively manage your weight unless you’re in a calorie deficit. 

Eat smaller meals more regularly, that are low in sugar and processed carbs, and high in fiber and protein to give you additional blood sugar control. Try to avoid energy-dense, calorie-rich foods, or those high in fat. Not only do these defeat the purpose of the drug, they may also worsen gastrointestinal side effects.

In terms of exercise, it’s beneficial to have a consistent workout routine that incorporates both aerobic activities, like walking or swimming, and muscle building activities like weight training. These are all fat burning activities that will boost your metabolism and improve your overall fitness. 

Finally, ensure you drink plenty of water! Not only is it important to stay hydrated but this can help you feel satiated.

How Long Does it Take to Lose Weight on Ozempic?

The speed of your weight management progress on Ozempic can vary based on a number of factors, including starting weight, dosage, and adherence to a healthy diet. The amount of body mass you lose may be accelerated if you’re able to adhere to lifestyle changes.

In general, you can expect to wait a few weeks before starting to see significant results.

The Role of Good Sleep

We’re only recently realizing just how important good sleep is for all aspects of health. Your weight management can be positively impacted by consistent sleep patterns, and getting a good night’s sleep will help you make good food choices. 

Mental Health Matters

Stress and anxiety have been shown to impact your food choices — they can cause overeating or binge eating, which slows down your weight management progress.

Be mindful of your mental health and if you can, integrate practices like mindfulness, yoga, and meditation. 

Therapy can also be extremely helpful, especially if you have underlying issues with food. Weight management is often just as much psychological as physical, so pay attention to your overall well-being and mental health!

Key Takeaways

Ozempic and its key ingredient semaglutide has shown significant promise as a weight management tool. It is a GLP-1 receptor agonist, which mimics the action of GLP-1 in your body, reducing hunger, slowing digestion, and controlling blood sugar. 

Whether or not you’re a suitable candidate for Ozempic will depend on your health conditions, current weight, and medications. A consultation with your medical team is essential before starting the medication. 

Ozempic has additional benefits above and beyond weight management, including blood sugar control, better metabolic health, and reduced risk of cardiovascular events.

The medication comes in injectable form with four strength options (0.25 mg, 0.5 mg, 1 mg, and 2 mg) to customize dosage according to individual needs. The maximum dose is 2 mg per week.

There are some side effects associated with Ozempic, primarily gastrointestinal. It is not suitable for everyone to take — it’s contraindicated for those with certain health conditions, including thyroid tumors, and type-1 diabetes. 

Lifestyle modifications such as maintaining a balanced diet and regular exercise are recommended to optimize the benefits of the medication. 

It’s important to remember that your weight management results on Ozempic may vary based on numerous factors including your starting body weight, dosage, and diet compliance.

If you have any questions about starting Ozempic, talk to your medical team, who will be able to advise you further.

Frequently Asked Questions (FAQs)

Can Ozempic be used in combination with other weight loss drugs?

While it is possible to use Ozempic alongside other weight management drugs, it could put you at risk of negative interactions and side effects, and is therefore not recommended. This is especially true if the other drugs you are taking are also GLP-1 receptor agonists, which could lead to exacerbated side effects and low blood sugar. 

It is considered both safe and healthy to aim for around two pounds of body mass loss per week. However, this is best achieved by combining your Ozempic medication with lifestyle changes, such as a healthy diet and exercise.

If you are considering using Ozempic in combination with other drugs, be sure to talk to your medical team first.

How does Ozempic compare with other weight loss treatments?

Ozempic’s effectiveness as a weight management tool has been demonstrated in several clinical trials, making it a reliable choice for many individuals. Compared to other products on the market, Ozempic is similar to other GLP-1 receptor agonist drugs, including Wegovy, Rybelsus, and Trulicity. 

Is it safe to stop using Ozempic suddenly after achieving weight loss goals?

While it is safe to stop using Ozempic suddenly, you may find that your cravings return and you regain a large proportion of your lost body mass. This is why it’s often recommended for long-term use.

It is best to stop taking Ozempic gradually under the supervision of your medical team, so they can monitor your progress and change your dosage if necessary. If you have to stop taking the drug suddenly for cost or insurance reasons, you’ll need to make sure you maintain your healthy lifestyle changes so that you can maintain your weight management progress.

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